A-3 Cingulo-Opercular and Frontoparietal Control Network Connectivity and Executive Functioning in Older Adults

Abstract Objective Executive functioning is a cognitive domain that typically declines with normal aging. Age-related disrupted connectivity in cingulo-opercular (CON) and frontoparietal control (FPCN) resting-state networks associated worse performance across various executive tasks. This study examines the relationships between CON FPCN older adults three subdomains: working memory, inhibition, set-shifting. Methods 274 healthy (age M = 71.7, SD 5.1; 87% Caucasian) from clinical trial at University of Florida Arizona completed tasks memory (Digit Span Backwards [DSB]; Letter Number Sequencing [LNS]), inhibition (Stroop), set-shifting (Trail Making Test Part B [TMT-B]). Participants underwent functional magnetic resonance imaging. CONN Toolbox (18b) was used for extracting average within-network FPCN. Multiple linear regressions were conducted network predicting performance, controlling age, sex, education, scanner. Results Greater better on DSB (β 0.26, p < 0.001), LNS 0.23, Stroop 0.24, TMT-B −0.26, 0.001). 0.22, 0.001) 0.18, 0.002). Conclusions significantly memory. Future research should conduct regional analyses within these to identify intervention targets improve adults.